Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 1 MG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6. This neurotoxin shows potential for cancer research.
- Potent K+ channel blocker
- Targets voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6
- Displays tumor growth inhibition effect with hyperthermia in vivo studies
- White to off-white solid appearance
Medchemexpress LLC IIQLPEIVVV TFA | 99.9% | 1122.40 | 1 MG
IIQLPEIVVV TFA is a specific inhibitor of Drp1-Mff interaction. It can distinguish physiological from pathological fission and block physiological fission, leading to mitochondrial dysfunction. It can be used in the study of Huntington's disease.
- Specific inhibitor of Drp1-Mff interaction
- Distinguishes physiological from pathological fission
- Blocks physiological fission
- Leads to mitochondrial dysfunction
- Used in the study of Huntington's disease
- Purity of 99.91%
- White to off-white solid appearance
- Sequence: Ile-Ile-Gln-Leu-Pro-Glu-Ile-Val-Val-Val
Medchemexpress LLC c(avb6)-DOTA TFA | 98.6% | 1546.65 | 1 MG
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with the DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA shows a comparable affinity for αvβ6 integrin (IC50=0.8 nM) and can be utilized as a tumor diagnostic.
- Conjugate of αvβ6 integrin selective peptide ring
- Modified with DOTA chelator
- Lu(III) complex shows comparable affinity for αvβ6 integrin (IC50=0.8 nM)
- Can be utilized as a tumor diagnostic
- Intended for research use only
FUJIFILM BIOSCIENCES INC Trifluoroacetic Acid Solution (for Gradient Elution) | 76-05-1 | MFCD00004169 | 40mL
Trifluoroacetic Acid Solution (for Gradient Elution) | Putity: 25% | MW: 114.022 | 76-05-1 | MFCD00004169 | 40mL
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 (free base) | 5 MG
Thanatin TFA is an inducible cationic antimicrobial peptide (AMP) with a single-disulfide-bond-containing β-hairpin structure. It exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria, as well as various fungal species. This peptide functions by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption.
- Exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria.
- Effective against various species of fungi.
- Disrupts bacterial outer membrane.
- Potent inhibitory effect on NDM-1-producing E. coli and K. pneumoniae strains.
- Increases survival rates and decreases bacterial titers in infected mice.
- Rescues pathological damages in a dose-dependent manner in vivo.
Medchemexpress LLC VMIP-II (1-21) TFA | 5 MG
vMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. It interacts broadly with CC and CXC chemokine receptors, inhibiting CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM). This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C108H169N33O27S.xC2HF3O2
- Sequence: Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro
- Target: CXCR
- Pathway: GPCR/G protein; immunology/inflammation
Medchemexpress LLC Lys-bradykinin TFA | 00-00-0 | 99.9% | 1188.38 g/mol (free base) | C56H85N17O12 · xC2HF3O2 | 25 MG
Lys-bradykinin TFA is the trifluoroacetate salt form of the decapeptide kallidin (Lys-bradykinin). It is used as a research reagent and acts as a ligand for kallidin and bradykinin receptors, supporting studies in vascular regulation, inflammation, and pain signaling.
- TFA salt form of lys-bradykinin (kallidin).
- High purity (≈99.85%).
- Molecular weight 1188.38 g/mol (free base).
- Provided in small quantities suitable for biochemical assays; 25 mg size available.
- Intended for receptor binding and vascular biology research applications.
Medchemexpress LLC KRFK TFA | 99.8% | 577.73 (free base) | 5 MG
KRFK TFA is a peptide derived from TSP-1 that activates TGF-β. It promotes TGF-β-mediated signaling and its downstream role, independently of thrombospondin (TSP) receptors like CD47 and CD36. KRFK TFA is used in research for chronic ocular surface inflammatory disorders.
- Activates TGF-β.
- Promotes TGF-β-mediated signaling.
- Acts independently of thrombospondin (TSP) receptors (CD47 and CD36).
- Can be used for chronic ocular surface inflammatory disorders research.
Medchemexpress LLC WD6305 TFA | 99.8% | 1226.40 | 1 MG
WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. It has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. It also exhibits antitumor activity.
- Potent and selective PROTAC degrader.
- Inhibits m6A modification and proliferation of AML cells.
- Induces apoptosis.
- Has antitumor activity.
- For research use only.
Medchemexpress LLC FRETS-VWF73 TFA | 97.4% | 9340.61 | 5 MG
FRETS-VWF73 TFA is a 73-amino-acid peptide that functions as a fluorogenic substrate for ADAMTS13 assay.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Excitation at 340 nm
- Emission at 450 nm
Medchemexpress LLC Peptide R TFA | 98.3% | 900.08 | 5 MG
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It exhibits outstanding capacities to remodel the tumor stroma and can be used for solid tumor research, including glioblastoma.
- Synthetic and specific CXCR4 antagonist
- Exhibits outstanding capacities to remodel the tumor stroma
- Can be used for solid tumor research, including glioblastoma
- Molecular weight is 900.08 (free base)
- Appears as a white to off-white solid
- Sequence is Arg-Ala-Cys-Arg-Phe-Phe-Cys with a disulfide bridge at Cys3-Cys7
Medchemexpress LLC M65 TFA | 99.98% | 4823.53 (free base) | 1 MG
M65 TFA is a deleted peptide of maxadilan (61 a.a.) with a deletion of residues between positions 24 and 42. It acts as a specific antagonist of the PACAP type 1 receptor, inhibiting ANP secretion, and can be utilized for relevant research purposes.
- Specific antagonist of the PACAP type 1 receptor.
- Inhibits ANP secretion.
- Suitable for research.
- In vitro activity: M65 (1 μM) completely blocks cAMP accumulation stimulated by 100 nM of VIP and partially inhibits cAMP accumulation stimulated by 1 nM of maxadilan in rat cortical neurons.
Medchemexpress LLC DLPLTFGGGTK TFA | MFCD34187350 | 98.1% | 1219.26 | 1 MG
DLPLTFGGGTK TFA is a synthetic peptide, presented as a white to off-white solid. It is a surrogate peptide for pembrolizumab identification and has been tested to comply with given specifications. This high-purity product (98.11%) is intended for research use only.
- White to off-white solid
- Surrogate peptide for pembrolizumab identification
- High purity of 98.11%
- Molecular weight of 1219.26
- Intended for research use